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Image Search Results
Journal: International Journal of Pharmaceutics: X
Article Title: Nanomedicines for DNA and interference RNA co-delivery: Combined gene therapy for Fabry disease
doi: 10.1016/j.ijpx.2026.100555
Figure Lengend Snippet: Schematic representation of combined gene therapy for FD. α-Gal A: α-Galactosidase A. pDNA: Plasmid DNA. Gb3S: Globotriaosylceramide synthase. siRNA: Small interference RNA. FD: Fabry disease. gSRT: Genetic substrate reduction therapy. Gb3: Globotriaosylceramide.
Article Snippet: Agarose, deoxyribonuclease I (DNAse I) and sodium dodecyl sulfate (SDS) were purchased from Sigma-Aldrich, GelRedTM from Biotium (Fremont, CA, USA) and GeneRuler Ultra Low Range DNA Ladder and 1
Techniques: Plasmid Preparation
Journal: International Journal of Pharmaceutics: X
Article Title: Nanomedicines for DNA and interference RNA co-delivery: Combined gene therapy for Fabry disease
doi: 10.1016/j.ijpx.2026.100555
Figure Lengend Snippet: Binding, protection and release capacity of co-delivery vectors with SLNs containing DOTAP or DOTAP/MC3. In all gels, lane 1 corresponds to 1 Kb pDNA ladder. Lane 2 to naked pCMV6-AC-αGLA, lane 3 to naked pCMV6-AC-αGLA + SDS, lane 4 to naked siRNA, lane 5 to siRNA + SDS, lane 6 to siRNA-GN + SDS, lane 11 to naked pR-M10-αGal A and lane 12 to Naked siRNA + DNase + SDS. ( A ) DxP3GNSLNEE co-delivery vectors: (7) DxP3GN5-ET. (8) DxP3GN2.5-ET. (9) DxP3GN5-EMC3. (10) DxP3GN2.5-EMC3. (13) DxP3GN5-ET vector + DNase + SDS. (14) DxP3GN2.5-ET vector + DNase + SDS. (15) DxP3GN5-EMC3 + DNase + SDS. (16) DxP3GN2.5-EMC3 + DNase + SDS. (17) DxP3GN5-ET + SDS. (18) DxP3GN2.5-ET + SDS. (19) DxP3GN5-EMC3 + SDS. (20) DxP3GN2.5-EMC3 + SDS. (B) HAP3GNSLNEE co-delivery vectors: (7) HAP3GN5-ET. (8). HAP3GN2.5-ET. (9) HAP3GN5-EMC3. (10) HAP3GN2.5-EMC3. (13) HAP3GN5-ET + DNase + SDS. (14) HAP3GN2.5-ET + DNase + SDS. (15) HAP3GN5-EMC3 + DNase + SDS. (16) HAP3GN2.5-EMC3 + DNase + SDS. (17) HAP3GN5-ET + SDS. (18) HAP3GN2.5-ET + SDS. (19) HAP3GN5-EMC3 + SDS. (20) HAP3GN2.5-EMC3 + SDS. ( C ) DxP2GNSLNEE co-delivery vectors: (7) DxP2GN5-ET. (8). DxP2GN2.5-ET. (9) DxP2GN5-EMC3. (10) DxP2GN2.5-EMC3. (13) DxP3GN5-ET + DNase + SDS. (14) DxP3GN2.5-ET + DNase + SDS. (15) DxP2GN5-EMC3 + DNase + SDS. (16) DxP2GN2.5-EMC3 + DNase + SDS. (17) DxP2GN5-ET + SDS. (18) DxP2GN2.5-ET + SDS. (19) DxP2GN5-EMC3 + SDS. (20) DxP2GN2.5-EMC3 + SDS. ( D ) HAP2GNSLEE co-delivery vectors: (7) HAP2GN5-ET. (8). HAP2GN2.5-ET. (9) HAP2GN5-EMC3. (10) HAP2GN2.5-EMC3. (13) HAP2GN5-ET + DNase + SDS. (14) HAP2GN2.5-ET + DNase + SDS. (15) HAP2GN5-EMC3 + DNase + SDS. (16) HAP2GN2.5-EMC3 + DNase + SDS. (17) HAP2GN5-ET + SDS. (18) HAP2GN2.5-ET + SDS. (19) HAP2GN5-EMC3 + SDS. (20) HAP2GN2.5-EMC3 + SDS.
Article Snippet: Agarose, deoxyribonuclease I (DNAse I) and sodium dodecyl sulfate (SDS) were purchased from Sigma-Aldrich, GelRedTM from Biotium (Fremont, CA, USA) and GeneRuler Ultra Low Range DNA Ladder and 1
Techniques: Binding Assay, Plasmid Preparation